COX6C-DDX27 Fusion FISH Probe
The COX6C-DDX27 Fusion FISH Probe is used to confirm a fusion of the COX6C and DDX27 genes. The fusion of the COX6C and DDX27 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COX6C-DDX27-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-RERE | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-REOR | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-REGO | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-REGR | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-REAQ | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-ORRE | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-OROR | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-ORGO | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-ORAQ | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-GORE | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-GOOR | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-GOGO | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-GOGR | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-GOAQ | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-GRRE | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-GROR | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-GRGO | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-GRGR | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-GRAQ | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-AQRE | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-AQOR | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-AQGO | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-AQGR | 20 (40 μL) | 200 μL |
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| COX6C-DDX27-20-AQAQ | 20 (40 μL) | 200 μL |
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COX6C Gene Summary
Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]
Gene Name: Cytochrome C Oxidase Subunit 6C
Chromosome: CHR8: 100890222 -100906242
Locus: 8q22.2
DDX27 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]
Gene Name: DEAD-box Helicase 27
Chromosome: CHR20: 47835831 -47860614
Locus: 20q13.13
Gene Diseases
The COX6C DDX27 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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