COX6A1-PPP1R12A Fusion FISH Probe
The COX6A1-PPP1R12A Fusion FISH Probe is used to confirm a fusion of the COX6A1 and PPP1R12A genes. The fusion of the COX6A1 and PPP1R12A genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COX6A1-PPP1R12A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-RERE | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-REOR | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-REGO | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-REGR | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-REAQ | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-ORRE | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-OROR | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-ORGO | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-ORAQ | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-GORE | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-GOOR | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-GOGO | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-GOGR | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-GOAQ | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-GRRE | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-GROR | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-GRGO | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-GRGR | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-GRAQ | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-AQRE | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-AQOR | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-AQGO | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-AQGR | 20 (40 μL) | 200 μL |
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| COX6A1-PPP1R12A-20-AQAQ | 20 (40 μL) | 200 μL |
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COX6A1 Gene Summary
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. [provided by RefSeq, Jul 2008]
Gene Name: Cytochrome C Oxidase Subunit 6A1
Chromosome: CHR12: 120875903 -120878529
Locus: 12q24.2
PPP1R12A Gene Summary
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 12A
Chromosome: CHR12: 80167342 -80329235
Locus: 12q21.2-q21.31
Gene Diseases
The COX6A1 PPP1R12A Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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