CORO7-TRAF7 Fusion FISH Probe
The CORO7-TRAF7 Fusion FISH Probe is used to confirm a fusion of the CORO7 and TRAF7 genes. The fusion of the CORO7 and TRAF7 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CORO7-TRAF7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-RERE | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-REOR | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-REGO | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-REGR | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-REAQ | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-ORRE | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-OROR | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-ORGO | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-ORAQ | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-GORE | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-GOOR | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-GOGO | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-GOGR | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-GOAQ | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-GRRE | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-GROR | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-GRGO | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-GRGR | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-GRAQ | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-AQRE | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-AQOR | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-AQGO | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-AQGR | 20 (40 μL) | 200 μL |
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| CORO7-TRAF7-20-AQAQ | 20 (40 μL) | 200 μL |
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CORO7 Gene Summary
This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]
Gene Name: Coronin 7
Chromosome: CHR16: 4404542 -4466962
Locus: 16p13.3
TRAF7 Gene Summary
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
Gene Name: TNF Receptor Associated Factor 7
Chromosome: CHR16: 2205798 -2228130
Locus: 16p13.3
Gene Diseases
The CORO7 TRAF7 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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