COQ6-ACOT4 Fusion FISH Probe
The COQ6-ACOT4 Fusion FISH Probe is used to confirm a fusion of the COQ6 and ACOT4 genes. The fusion of the COQ6 and ACOT4 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COQ6-ACOT4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-RERE | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-REOR | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-REGO | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-REGR | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-REAQ | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-ORRE | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-OROR | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-ORGO | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-ORAQ | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-GORE | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-GOOR | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-GOGO | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-GOGR | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-GOAQ | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-GRRE | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-GROR | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-GRGO | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-GRGR | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-GRAQ | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-AQRE | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-AQOR | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-AQGO | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-AQGR | 20 (40 μL) | 200 μL |
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| COQ6-ACOT4-20-AQAQ | 20 (40 μL) | 200 μL |
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COQ6 Gene Summary
The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2012]
Gene Name: Coenzyme Q6, Monooxygenase
Chromosome: CHR14: 74416636 -74429813
Locus: 14q24.3
ACOT4 Gene Summary
The Acyl-CoA Thioesterase 4 (ACOT4) gene is located on chr14 :74058409-74062470 at 14q24.3.
Gene Name: Acyl-CoA Thioesterase 4
Chromosome: CHR14: 74058409 -74062470
Locus: 14q24.3
Gene Diseases
The COQ6 ACOT4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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