COMT-ZDHHC11 Fusion FISH Probe
The COMT-ZDHHC11 Fusion FISH Probe is used to confirm a fusion of the COMT and ZDHHC11 genes. The fusion of the COMT and ZDHHC11 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COMT-ZDHHC11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-RERE | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-REOR | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-REGO | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-REGR | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-REAQ | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-ORRE | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-OROR | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-ORGO | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-ORAQ | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-GORE | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-GOOR | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-GOGO | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-GOGR | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-GOAQ | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-GRRE | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-GROR | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-GRGO | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-GRGR | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-GRAQ | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-AQRE | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-AQOR | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-AQGO | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-AQGR | 20 (40 μL) | 200 μL |
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| COMT-ZDHHC11-20-AQAQ | 20 (40 μL) | 200 μL |
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COMT Gene Summary
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
Gene Name: Catechol-O-methyltransferase
Chromosome: CHR22: 19929262 -19957498
Locus: 22q11.21
ZDHHC11 Gene Summary
The Zinc Finger DHHC-type Containing 11 (ZDHHC11) gene is located on chr5 :795719-851101 at 5p15.33.
Gene Name: Zinc Finger DHHC-type Containing 11
Chromosome: CHR5: 795719 -851101
Locus: 5p15.33
Gene Diseases
The COMT ZDHHC11 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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