COL6A1-PLAT Fusion FISH Probe
The COL6A1-PLAT Fusion FISH Probe is used to confirm a fusion of the COL6A1 and PLAT genes. The fusion of the COL6A1 and PLAT genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL6A1-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| COL6A1-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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COL6A1 Gene Summary
The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy. [provided by RefSeq, Jul 2008]
Gene Name: Collagen Type VI Alpha 1 Chain
Chromosome: CHR21: 47401662 -47424963
Locus: 21q22.3
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The COL6A1 PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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