COL6A1-EIF2AK2 Fusion FISH Probe
The COL6A1-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the COL6A1 and EIF2AK2 genes. The fusion of the COL6A1 and EIF2AK2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL6A1-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| COL6A1-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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COL6A1 Gene Summary
The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy. [provided by RefSeq, Jul 2008]
Gene Name: Collagen Type VI Alpha 1 Chain
Chromosome: CHR21: 47401662 -47424963
Locus: 21q22.3
EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
Gene Diseases
The COL6A1 EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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