COL5A1-UVRAG Fusion FISH Probe
The COL5A1-UVRAG Fusion FISH Probe is used to confirm a fusion of the COL5A1 and UVRAG genes. The fusion of the COL5A1 and UVRAG genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL5A1-UVRAG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-RERE | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-REOR | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-REGO | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-REGR | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-REAQ | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-ORRE | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-OROR | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-ORGO | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-GORE | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-GOOR | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-GOGO | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-GOGR | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-GRRE | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-GROR | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-GRGO | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-GRGR | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-AQRE | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-AQOR | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-AQGO | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-AQGR | 20 (40 μL) | 200 μL |
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| COL5A1-UVRAG-20-AQAQ | 20 (40 μL) | 200 μL |
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COL5A1 Gene Summary
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Name: Collagen Type V Alpha 1 Chain
Chromosome: CHR9: 137533651 -137736688
Locus: 9q34.3
UVRAG Gene Summary
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Gene Name: UV Radiation Resistance Associated
Chromosome: CHR11: 75526211 -75855282
Locus: 11q13.5
Gene Diseases
The COL5A1 UVRAG Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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