COL5A1-DDX21 Fusion FISH Probe
The COL5A1-DDX21 Fusion FISH Probe is used to confirm a fusion of the COL5A1 and DDX21 genes. The fusion of the COL5A1 and DDX21 genes has been associated with Uterine Carcinosarcoma, and Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL5A1-DDX21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-RERE | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-REOR | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-REGO | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-REGR | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-REAQ | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-ORRE | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-OROR | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-ORGO | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-GORE | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-GOOR | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-GOGO | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-GOGR | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-GRRE | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-GROR | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-GRGO | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-GRGR | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-AQRE | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-AQOR | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-AQGO | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-AQGR | 20 (40 μL) | 200 μL |
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| COL5A1-DDX21-20-AQAQ | 20 (40 μL) | 200 μL |
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COL5A1 Gene Summary
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Name: Collagen Type V Alpha 1 Chain
Chromosome: CHR9: 137533651 -137736688
Locus: 9q34.3
DDX21 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
Gene Name: DExD-box Helicase 21
Chromosome: CHR10: 70715891 -70744279
Locus: 10q22.1
Gene Diseases
The COL5A1 DDX21 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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