COL4A5-RNF128 Fusion FISH Probe
The COL4A5-RNF128 Fusion FISH Probe is used to confirm a fusion of the COL4A5 and RNF128 genes. The fusion of the COL4A5 and RNF128 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL4A5-RNF128-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-RERE | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-REOR | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-REGO | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-REGR | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-REAQ | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-ORRE | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-OROR | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-ORGO | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-GORE | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-GOOR | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-GOGO | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-GOGR | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-GRRE | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-GROR | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-GRGO | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-GRGR | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-AQRE | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-AQOR | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-AQGO | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-AQGR | 20 (40 μL) | 200 μL |
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| COL4A5-RNF128-20-AQAQ | 20 (40 μL) | 200 μL |
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COL4A5 Gene Summary
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
Gene Name: Collagen Type IV Alpha 5 Chain
Chromosome: CHRX: 107683153 -107940775
Locus: Xq22.3
RNF128 Gene Summary
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Ring Finger Protein 128, E3 Ubiquitin Protein Ligase
Chromosome: CHRX: 105937067 -106040246
Locus: Xq22.3
Gene Diseases
The COL4A5 RNF128 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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