COL3A1-SEC63 Fusion FISH Probe
The COL3A1-SEC63 Fusion FISH Probe is used to confirm a fusion of the COL3A1 and SEC63 genes. The fusion of the COL3A1 and SEC63 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL3A1-SEC63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-RERE | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-REOR | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-REGO | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-REGR | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-REAQ | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-ORRE | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-OROR | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-ORGO | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-GORE | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-GOOR | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-GOGO | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-GOGR | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-GRRE | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-GROR | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-GRGO | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-GRGR | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-AQRE | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-AQOR | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-AQGO | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-AQGR | 20 (40 μL) | 200 μL |
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| COL3A1-SEC63-20-AQAQ | 20 (40 μL) | 200 μL |
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COL3A1 Gene Summary
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
Gene Name: Collagen Type III Alpha 1 Chain
Chromosome: CHR2: 189839098 -189877472
Locus: 2q32.2
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The COL3A1 SEC63 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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