COL3A1-PLAT Fusion FISH Probe
The COL3A1-PLAT Fusion FISH Probe is used to confirm a fusion of the COL3A1 and PLAT genes. The fusion of the COL3A1 and PLAT genes has been associated with Testicular Germ Cell Tumors, and Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL3A1-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| COL3A1-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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COL3A1 Gene Summary
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
Gene Name: Collagen Type III Alpha 1 Chain
Chromosome: CHR2: 189839098 -189877472
Locus: 2q32.2
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The COL3A1 PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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