COL3A1-MMP14 Fusion FISH Probe
The COL3A1-MMP14 Fusion FISH Probe is used to confirm a fusion of the COL3A1 and MMP14 genes. The fusion of the COL3A1 and MMP14 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL3A1-MMP14-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-RERE | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-REOR | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-REGO | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-REGR | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-REAQ | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-ORRE | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-OROR | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-ORGO | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-GORE | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-GOOR | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-GOGO | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-GOGR | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-GRRE | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-GROR | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-GRGO | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-GRGR | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-AQRE | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-AQOR | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-AQGO | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-AQGR | 20 (40 μL) | 200 μL |
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| COL3A1-MMP14-20-AQAQ | 20 (40 μL) | 200 μL |
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COL3A1 Gene Summary
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
Gene Name: Collagen Type III Alpha 1 Chain
Chromosome: CHR2: 189839098 -189877472
Locus: 2q32.2
MMP14 Gene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
Gene Name: Matrix Metallopeptidase 14
Chromosome: CHR14: 23305792 -23316803
Locus: 14q11.2
Gene Diseases
The COL3A1 MMP14 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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