COL3A1-ERBB3 Fusion FISH Probe
The COL3A1-ERBB3 Fusion FISH Probe is used to confirm a fusion of the COL3A1 and ERBB3 genes. The fusion of the COL3A1 and ERBB3 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL3A1-ERBB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-RERE | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-REOR | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-REGO | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-REGR | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-REAQ | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-ORRE | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-OROR | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-ORGO | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-GORE | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-GOOR | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-GOGO | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-GOGR | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-GRRE | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-GROR | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-GRGO | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-GRGR | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-AQRE | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-AQOR | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-AQGO | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-AQGR | 20 (40 μL) | 200 μL |
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| COL3A1-ERBB3-20-AQAQ | 20 (40 μL) | 200 μL |
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COL3A1 Gene Summary
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
Gene Name: Collagen Type III Alpha 1 Chain
Chromosome: CHR2: 189839098 -189877472
Locus: 2q32.2
ERBB3 Gene Summary
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 3
Chromosome: CHR12: 56473808 -56497291
Locus: 12q13.2
Gene Diseases
The COL3A1 ERBB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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