COL21A1-DST Fusion FISH Probe
The COL21A1-DST Fusion FISH Probe is used to confirm a fusion of the COL21A1 and DST genes. The fusion of the COL21A1 and DST genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL21A1-DST-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-RERE | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-REOR | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-REGO | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-REGR | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-REAQ | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-ORRE | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-OROR | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-ORGO | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-GORE | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-GOOR | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-GOGO | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-GOGR | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-GRRE | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-GROR | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-GRGO | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-GRGR | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-AQRE | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-AQOR | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-AQGO | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-AQGR | 20 (40 μL) | 200 μL |
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| COL21A1-DST-20-AQAQ | 20 (40 μL) | 200 μL |
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DST Gene Summary
This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]
Gene Name: Dystonin
Chromosome: CHR6: 56322784 -56507694
Locus: 6p12.1
COL21A1 Gene Summary
This gene encodes the alpha chain of type XXI collagen, a member of the FACIT (fibril-associated collagens with interrupted helices) collagen family. Type XXI collagen is localized to tissues containing type I collagen and maintains the integrity of the extracellular matrix. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: Collagen Type XXI Alpha 1 Chain
Chromosome: CHR6: 55921387 -56112378
Locus: 6p12.3-p11.2
Gene Diseases
The COL21A1 DST Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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