COL18A1-SNW1 Fusion FISH Probe
The COL18A1-SNW1 Fusion FISH Probe is used to confirm a fusion of the COL18A1 and SNW1 genes. The fusion of the COL18A1 and SNW1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL18A1-SNW1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-RERE | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-REOR | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-REGO | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-REGR | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-REAQ | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-ORRE | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-OROR | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-ORGO | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-GORE | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-GOOR | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-GOGO | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-GOGR | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-GRRE | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-GROR | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-GRGO | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-GRGR | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-AQRE | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-AQOR | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-AQGO | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-AQGR | 20 (40 μL) | 200 μL |
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| COL18A1-SNW1-20-AQAQ | 20 (40 μL) | 200 μL |
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SNW1 Gene Summary
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: SNW Domain Containing 1
Chromosome: CHR14: 78183943 -78227497
Locus: 14q24.3
COL18A1 Gene Summary
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Collagen Type XVIII Alpha 1 Chain
Chromosome: CHR21: 46825096 -46933634
Locus: 21q22.3
Gene Diseases
The COL18A1 SNW1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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