COL18A1-ADARB1 Fusion FISH Probe
The COL18A1-ADARB1 Fusion FISH Probe is used to confirm a fusion of the COL18A1 and ADARB1 genes. The fusion of the COL18A1 and ADARB1 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COL18A1-ADARB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-RERE | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-REOR | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-REGO | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-REGR | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-REAQ | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-ORRE | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-OROR | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-ORGO | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-GORE | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-GOOR | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-GOGO | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-GOGR | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-GRRE | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-GROR | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-GRGO | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-GRGR | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-AQRE | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-AQOR | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-AQGO | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-AQGR | 20 (40 μL) | 200 μL |
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| COL18A1-ADARB1-20-AQAQ | 20 (40 μL) | 200 μL |
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ADARB1 Gene Summary
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]
Gene Name: Adenosine Deaminase, RNA Specific B1
Chromosome: CHR21: 46494492 -46646478
Locus: 21q22.3
COL18A1 Gene Summary
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Gene Name: Collagen Type XVIII Alpha 1 Chain
Chromosome: CHR21: 46825096 -46933634
Locus: 21q22.3
Gene Diseases
The COL18A1 ADARB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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