COG6-MAPK8 Fusion FISH Probe
The COG6-MAPK8 Fusion FISH Probe is used to confirm a fusion of the COG6 and MAPK8 genes. The fusion of the COG6 and MAPK8 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COG6-MAPK8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-RERE | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-REOR | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-REGO | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-REGR | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-REAQ | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-ORRE | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-OROR | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-ORGO | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-ORAQ | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-GORE | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-GOOR | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-GOGO | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-GOGR | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-GOAQ | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-GRRE | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-GROR | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-GRGO | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-GRGR | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-GRAQ | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-AQRE | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-AQOR | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-AQGO | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-AQGR | 20 (40 μL) | 200 μL |
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| COG6-MAPK8-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPK8 Gene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
Gene Name: Mitogen-activated Protein Kinase 8
Chromosome: CHR10: 49609686 -49643183
Locus: 10q11.22
COG6 Gene Summary
This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi apparatus. The encoded protein is organized with conserved oligomeric Golgi complex components 5, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
Gene Name: Component Of Oligomeric Golgi Complex 6
Chromosome: CHR13: 40229763 -40365802
Locus: 13q14.11
Gene Diseases
The COG6 MAPK8 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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