COBL-DUSP14 Fusion FISH Probe
The COBL-DUSP14 Fusion FISH Probe is used to confirm a fusion of the COBL and DUSP14 genes. The fusion of the COBL and DUSP14 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| COBL-DUSP14-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-RERE | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-REOR | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-REGO | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-REGR | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-REAQ | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-ORRE | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-OROR | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-ORGO | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-ORAQ | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-GORE | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-GOOR | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-GOGO | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-GOGR | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-GOAQ | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-GRRE | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-GROR | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-GRGO | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-GRGR | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-GRAQ | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-AQRE | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-AQOR | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-AQGO | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-AQGR | 20 (40 μL) | 200 μL |
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| COBL-DUSP14-20-AQAQ | 20 (40 μL) | 200 μL |
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DUSP14 Gene Summary
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Gene Name: Dual Specificity Phosphatase 14
Chromosome: CHR17: 35849950 -35873588
Locus: 17q12
COBL Gene Summary
This gene encodes a protein that contains WH2 domains (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that interact with actin. The encoded actin regulator protein is required for growth and assembly of brush border microvilli that play a role in maintaining intestinal homeostasis. A similar protein in mouse functions in midbrain neural tube closure. A pseudogene of this gene is located on chromosome X. [provided by RefSeq, Oct 2016]
Gene Name: Cordon-bleu WH2 Repeat Protein
Chromosome: CHR7: 51083908 -51384515
Locus: 7p12.1
Gene Diseases
The COBL DUSP14 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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