CNST-RAP1GAP Fusion FISH Probe
The CNST-RAP1GAP Fusion FISH Probe is used to confirm a fusion of the CNST and RAP1GAP genes. The fusion of the CNST and RAP1GAP genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CNST-RAP1GAP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-RERE | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-REOR | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-REGO | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-REGR | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-REAQ | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-ORRE | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-OROR | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-ORGO | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-ORAQ | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-GORE | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-GOOR | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-GOGO | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-GOGR | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-GOAQ | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-GRRE | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-GROR | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-GRGO | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-GRGR | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-GRAQ | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-AQRE | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-AQOR | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-AQGO | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-AQGR | 20 (40 μL) | 200 μL |
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| CNST-RAP1GAP-20-AQAQ | 20 (40 μL) | 200 μL |
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RAP1GAP Gene Summary
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Gene Name: RAP1 GTPase Activating Protein
Chromosome: CHR1: 21922707 -21995856
Locus: 1p36.12
CNST Gene Summary
Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]
Gene Name: Consortin, Connexin Sorting Protein
Chromosome: CHR1: 246729638 -246831884
Locus: 1q44
Gene Diseases
The CNST RAP1GAP Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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