CNST-LNX1 Fusion FISH Probe
The CNST-LNX1 Fusion FISH Probe is used to confirm a fusion of the CNST and LNX1 genes. The fusion of the CNST and LNX1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CNST-LNX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-RERE | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-REOR | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-REGO | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-REGR | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-REAQ | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-ORRE | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-OROR | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-ORGO | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-GORE | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-GOOR | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-GOGO | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-GOGR | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-GRRE | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-GROR | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-GRGO | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-GRGR | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-AQRE | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-AQOR | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-AQGO | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-AQGR | 20 (40 μL) | 200 μL |
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| CNST-LNX1-20-AQAQ | 20 (40 μL) | 200 μL |
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LNX1 Gene Summary
This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Ligand Of Numb-protein X 1
Chromosome: CHR4: 54326436 -54457724
Locus: 4q12
CNST Gene Summary
Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]
Gene Name: Consortin, Connexin Sorting Protein
Chromosome: CHR1: 246729638 -246831884
Locus: 1q44
Gene Diseases
The CNST LNX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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