CNOT2-SRGAP1 Fusion FISH Probe
The CNOT2-SRGAP1 Fusion FISH Probe is used to confirm a fusion of the CNOT2 and SRGAP1 genes. The fusion of the CNOT2 and SRGAP1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CNOT2-SRGAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-RERE | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-REOR | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-REGO | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-REGR | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-OROR | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-GORE | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-GROR | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| CNOT2-SRGAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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CNOT2 Gene Summary
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Name: CCR4-NOT Transcription Complex Subunit 2
Chromosome: CHR12: 70636773 -70748773
Locus: 12q15
SRGAP1 Gene Summary
The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016]
Gene Name: SLIT-ROBO Rho GTPase Activating Protein 1
Chromosome: CHR12: 64238540 -64541613
Locus: 12q14.2
Gene Diseases
The CNOT2 SRGAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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