CNOT2-FBXO4 Fusion FISH Probe
The CNOT2-FBXO4 Fusion FISH Probe is used to confirm a fusion of the CNOT2 and FBXO4 genes. The fusion of the CNOT2 and FBXO4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CNOT2-FBXO4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-RERE | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-REOR | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-REGO | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-REGR | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-REAQ | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-ORRE | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-OROR | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-ORGO | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-GORE | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-GOOR | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-GOGO | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-GOGR | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-GRRE | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-GROR | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-GRGO | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-GRGR | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-AQRE | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-AQOR | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-AQGO | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-AQGR | 20 (40 μL) | 200 μL |
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| CNOT2-FBXO4-20-AQAQ | 20 (40 μL) | 200 μL |
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CNOT2 Gene Summary
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Name: CCR4-NOT Transcription Complex Subunit 2
Chromosome: CHR12: 70636773 -70748773
Locus: 12q15
FBXO4 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: F-box Protein 4
Chromosome: CHR5: 41925355 -41941672
Locus: 5p13.1
Gene Diseases
The CNOT2 FBXO4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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