CNNM2-NOTCH4 Fusion FISH Probe
The CNNM2-NOTCH4 Fusion FISH Probe is used to confirm a fusion of the CNNM2 and NOTCH4 genes. The fusion of the CNNM2 and NOTCH4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CNNM2-NOTCH4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-RERE | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-REOR | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-REGO | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-REGR | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-REAQ | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-ORRE | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-OROR | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-ORGO | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-GORE | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-GOOR | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-GOGO | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-GOGR | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-GRRE | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-GROR | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-GRGO | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-GRGR | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-AQRE | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-AQOR | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-AQGO | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-AQGR | 20 (40 μL) | 200 μL |
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| CNNM2-NOTCH4-20-AQAQ | 20 (40 μL) | 200 μL |
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NOTCH4 Gene Summary
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Notch 4
Chromosome: CHR6_mann_hap4: 3505440 -3534689
Locus: 6p21.32
CNNM2 Gene Summary
This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 2
Chromosome: CHR10: 104678113 -104838240
Locus: 10q24.32
Gene Diseases
The CNNM2 NOTCH4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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