CMTM8-RPN1 Fusion FISH Probe
The CMTM8-RPN1 Fusion FISH Probe is used to confirm a fusion of the CMTM8 and RPN1 genes. The fusion of the CMTM8 and RPN1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CMTM8-RPN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-RERE | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-REOR | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-REGO | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-REGR | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-REAQ | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-ORRE | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-OROR | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-ORGO | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-GORE | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-GOOR | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-GOGO | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-GOGR | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-GRRE | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-GROR | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-GRGO | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-GRGR | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-AQRE | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-AQOR | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-AQGO | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-AQGR | 20 (40 μL) | 200 μL |
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| CMTM8-RPN1-20-AQAQ | 20 (40 μL) | 200 μL |
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RPN1 Gene Summary
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
Gene Name: Ribophorin I
Chromosome: CHR3: 128338812 -128369719
Locus: 3q21.3
CMTM8 Gene Summary
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Gene Name: CKLF Like MARVEL Transmembrane Domain Containing 8
Chromosome: CHR3: 32280170 -32411813
Locus: 3p22.3
Gene Diseases
The CMTM8 RPN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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