CMTM7-CLDN11 Fusion FISH Probe
The CMTM7-CLDN11 Fusion FISH Probe is used to confirm a fusion of the CMTM7 and CLDN11 genes. The fusion of the CMTM7 and CLDN11 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CMTM7-CLDN11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-RERE | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-REOR | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-REGO | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-REGR | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-REAQ | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-ORRE | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-OROR | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-ORGO | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-ORAQ | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-GORE | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-GOOR | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-GOGO | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-GOGR | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-GOAQ | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-GRRE | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-GROR | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-GRGO | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-GRGR | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-GRAQ | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-AQRE | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-AQOR | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-AQGO | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-AQGR | 20 (40 μL) | 200 μL |
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| CMTM7-CLDN11-20-AQAQ | 20 (40 μL) | 200 μL |
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CLDN11 Gene Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]
Gene Name: Claudin 11
Chromosome: CHR3: 170136652 -170152479
Locus: 3q26.2
CMTM7 Gene Summary
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Gene Name: CKLF Like MARVEL Transmembrane Domain Containing 7
Chromosome: CHR3: 32433162 -32496333
Locus: 3p22.3
Gene Diseases
The CMTM7 CLDN11 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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