CMTM4-KLHL24 Fusion FISH Probe
The CMTM4-KLHL24 Fusion FISH Probe is used to confirm a fusion of the CMTM4 and KLHL24 genes. The fusion of the CMTM4 and KLHL24 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CMTM4-KLHL24-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-RERE | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-REOR | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-REGO | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-REGR | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-REAQ | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-ORRE | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-OROR | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-ORGO | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-ORAQ | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-GORE | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-GOOR | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-GOGO | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-GOGR | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-GOAQ | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-GRRE | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-GROR | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-GRGO | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-GRGR | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-GRAQ | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-AQRE | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-AQOR | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-AQGO | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-AQGR | 20 (40 μL) | 200 μL |
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| CMTM4-KLHL24-20-AQAQ | 20 (40 μL) | 200 μL |
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KLHL24 Gene Summary
The protein encoded by this gene is a ubiquitin ligase substrate receptor and is regulated by autoubiquitination. Variations in the translation initiation codon of this gene have been found, which result in an N-terminally truncated but more stable protein due to loss of the autoubiquitination function. The more stable mutant protein causes an increased ubiquitin and degradation of keratin 14, which leads to skin fragility and the potentially life-threatening disease epidermolysis bullosa. The encoded protein is also involved in the regulation of kainate receptors. [provided by RefSeq, Mar 2017]
Gene Name: Kelch Like Family Member 24
Chromosome: CHR3: 183353410 -183402304
Locus: 3q27.1
CMTM4 Gene Summary
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: CKLF Like MARVEL Transmembrane Domain Containing 4
Chromosome: CHR16: 66648652 -66730610
Locus: 16q21-q22.1
Gene Diseases
The CMTM4 KLHL24 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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