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CLTC-ROS1 Fusion FISH Probe

The CLTC-ROS1 Fusion FISH Probe is used to confirm a fusion of the CLTC and ROS1 genes. The fusion of the CLTC and ROS1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CLTC-ROS1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CLTC-ROS1-20-RERE 20 (40 μL) 200 μL
CLTC-ROS1-20-REOR 20 (40 μL) 200 μL
CLTC-ROS1-20-REGO 20 (40 μL) 200 μL
CLTC-ROS1-20-REGR 20 (40 μL) 200 μL
CLTC-ROS1-20-REAQ 20 (40 μL) 200 μL
CLTC-ROS1-20-ORRE 20 (40 μL) 200 μL
CLTC-ROS1-20-OROR 20 (40 μL) 200 μL
CLTC-ROS1-20-ORGO 20 (40 μL) 200 μL
CLTC-ROS1-20-ORAQ 20 (40 μL) 200 μL
CLTC-ROS1-20-GORE 20 (40 μL) 200 μL
CLTC-ROS1-20-GOOR 20 (40 μL) 200 μL
CLTC-ROS1-20-GOGO 20 (40 μL) 200 μL
CLTC-ROS1-20-GOGR 20 (40 μL) 200 μL
CLTC-ROS1-20-GOAQ 20 (40 μL) 200 μL
CLTC-ROS1-20-GRRE 20 (40 μL) 200 μL
CLTC-ROS1-20-GROR 20 (40 μL) 200 μL
CLTC-ROS1-20-GRGO 20 (40 μL) 200 μL
CLTC-ROS1-20-GRGR 20 (40 μL) 200 μL
CLTC-ROS1-20-GRAQ 20 (40 μL) 200 μL
CLTC-ROS1-20-AQRE 20 (40 μL) 200 μL
CLTC-ROS1-20-AQOR 20 (40 μL) 200 μL
CLTC-ROS1-20-AQGO 20 (40 μL) 200 μL
CLTC-ROS1-20-AQGR 20 (40 μL) 200 μL
CLTC-ROS1-20-AQAQ 20 (40 μL) 200 μL

CLTC Gene Summary

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]

Gene Name: Clathrin Heavy Chain

Chromosome: CHR17: 57697049 -57774317

Locus: 17q23.1

ROS1 Gene Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

Gene Name: ROS Proto-oncogene 1, Receptor Tyrosine Kinase

Chromosome: CHR6: 117609529 -117747018

Locus: 6q22.1

Gene Diseases

The CLTC ROS1 Fusion has been associated with the following diseases:

Disease Name
Lung Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Comprehensive Genomic Profiling of Malignant Effusions in Patients with Metastatic Lung Adenocarcinoma

In this study, the utility of performing targeted next-generation sequencing (NGS) on malignant effusions from patients with metastatic lung adenocarcinoma was investigated. NGS is a high throughput technology, which utilizes a small sample input, but the suitability of NGS analysis for tissue-free cytology samples such as malignant body fluids is not well understood. In order to investigate the adequacy of NGS on liquid biopsies of MLA, targeted NGS was performed using custom target panels consisting of many oncogenes. Additional non-NGS molecular tests were performed on the effusion samples, including fluorescence in situ hybridization (FISH) analysis for the oncogene ROS1, using a break-apart FISH probe manufactured by Empire Genomics.