CLTC-PTRH2 Fusion FISH Probe
The CLTC-PTRH2 Fusion FISH Probe is used to confirm a fusion of the CLTC and PTRH2 genes. The fusion of the CLTC and PTRH2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLTC-PTRH2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-RERE | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-REOR | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-REGO | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-REGR | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-REAQ | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-ORRE | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-OROR | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-ORGO | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-GORE | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-GOOR | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-GOGO | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-GOGR | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-GRRE | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-GROR | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-GRGO | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-GRGR | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-AQRE | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-AQOR | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-AQGO | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-AQGR | 20 (40 μL) | 200 μL |
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| CLTC-PTRH2-20-AQAQ | 20 (40 μL) | 200 μL |
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CLTC Gene Summary
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]
Gene Name: Clathrin Heavy Chain
Chromosome: CHR17: 57697049 -57774317
Locus: 17q23.1
PTRH2 Gene Summary
The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Gene Name: Peptidyl-tRNA Hydrolase 2
Chromosome: CHR17: 57774666 -57784856
Locus: 17q23.1
Gene Diseases
The CLTC PTRH2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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