CLPB-SHANK2 Fusion FISH Probe
The CLPB-SHANK2 Fusion FISH Probe is used to confirm a fusion of the CLPB and SHANK2 genes. The fusion of the CLPB and SHANK2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLPB-SHANK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-RERE | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-REOR | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-REGO | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-REGR | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-REAQ | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-ORRE | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-OROR | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-ORGO | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-GORE | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-GOOR | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-GOGO | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-GOGR | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-GRRE | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-GROR | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-GRGO | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-GRGR | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-AQRE | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-AQOR | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-AQGO | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-AQGR | 20 (40 μL) | 200 μL |
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| CLPB-SHANK2-20-AQAQ | 20 (40 μL) | 200 μL |
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SHANK2 Gene Summary
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Name: SH3 And Multiple Ankyrin Repeat Domains 2
Chromosome: CHR11: 70313960 -70935808
Locus: 11q13.3-q13.4
CLPB Gene Summary
This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Name: ClpB Homolog, Mitochondrial AAA ATPase Chaperonin
Chromosome: CHR11: 72003469 -72145568
Locus: 11q13.4
Gene Diseases
The CLPB SHANK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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