CLPB-PTPN1 Fusion FISH Probe
The CLPB-PTPN1 Fusion FISH Probe is used to confirm a fusion of the CLPB and PTPN1 genes. The fusion of the CLPB and PTPN1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLPB-PTPN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-RERE | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-REOR | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-REGO | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-REGR | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-REAQ | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-ORRE | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-OROR | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-ORGO | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-GORE | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-GOOR | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-GOGO | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-GOGR | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-GRRE | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-GROR | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-GRGO | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-GRGR | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-AQRE | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-AQOR | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-AQGO | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-AQGR | 20 (40 μL) | 200 μL |
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| CLPB-PTPN1-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN1 Gene Summary
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 1
Chromosome: CHR20: 49126890 -49201086
Locus: 20q13.13
CLPB Gene Summary
This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Name: ClpB Homolog, Mitochondrial AAA ATPase Chaperonin
Chromosome: CHR11: 72003469 -72145568
Locus: 11q13.4
Gene Diseases
The CLPB PTPN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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