CLPB-FCHSD2 Fusion FISH Probe
The CLPB-FCHSD2 Fusion FISH Probe is used to confirm a fusion of the CLPB and FCHSD2 genes. The fusion of the CLPB and FCHSD2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLPB-FCHSD2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-RERE | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-REOR | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-REGO | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-REGR | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-REAQ | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-ORRE | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-OROR | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-ORGO | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-GORE | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-GOOR | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-GOGO | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-GOGR | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-GRRE | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-GROR | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-GRGO | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-GRGR | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-AQRE | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-AQOR | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-AQGO | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-AQGR | 20 (40 μL) | 200 μL |
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| CLPB-FCHSD2-20-AQAQ | 20 (40 μL) | 200 μL |
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FCHSD2 Gene Summary
The FCH And Double SH3 Domains 2 (FCHSD2) gene is located on chr11 :72547789-72853143 at 11q13.4.
Gene Name: FCH And Double SH3 Domains 2
Chromosome: CHR11: 72547789 -72853143
Locus: 11q13.4
CLPB Gene Summary
This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Name: ClpB Homolog, Mitochondrial AAA ATPase Chaperonin
Chromosome: CHR11: 72003469 -72145568
Locus: 11q13.4
Gene Diseases
The CLPB FCHSD2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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