CLOCK-SRD5A3 Fusion FISH Probe
The CLOCK-SRD5A3 Fusion FISH Probe is used to confirm a fusion of the CLOCK and SRD5A3 genes. The fusion of the CLOCK and SRD5A3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLOCK-SRD5A3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-RERE | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-REOR | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-REGO | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-REGR | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-REAQ | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-ORRE | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-OROR | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-ORGO | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-GORE | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-GOOR | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-GOGO | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-GOGR | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-GRRE | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-GROR | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-GRGO | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-GRGR | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-AQRE | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-AQOR | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-AQGO | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-AQGR | 20 (40 μL) | 200 μL |
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| CLOCK-SRD5A3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLOCK Gene Summary
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: Clock Circadian Regulator
Chromosome: CHR4: 56298659 -56412997
Locus: 4q12
SRD5A3 Gene Summary
The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. This protein is also necessary for the conversion of polyprenol into dolichol, which is required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-linked glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type Iq. [provided by RefSeq, Mar 2011]
Gene Name: Steroid 5 Alpha-reductase 3
Chromosome: CHR4: 56212387 -56239266
Locus: 4q12
Gene Diseases
The CLOCK SRD5A3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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