CLOCK-PHF21A Fusion FISH Probe
The CLOCK-PHF21A Fusion FISH Probe is used to confirm a fusion of the CLOCK and PHF21A genes. The fusion of the CLOCK and PHF21A genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLOCK-PHF21A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-RERE | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-REOR | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-REGO | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-REGR | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-REAQ | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-ORRE | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-OROR | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-ORGO | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-GORE | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-GOOR | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-GOGO | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-GOGR | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-GRRE | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-GROR | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-GRGO | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-GRGR | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-AQRE | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-AQOR | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-AQGO | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-AQGR | 20 (40 μL) | 200 μL |
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| CLOCK-PHF21A-20-AQAQ | 20 (40 μL) | 200 μL |
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CLOCK Gene Summary
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: Clock Circadian Regulator
Chromosome: CHR4: 56298659 -56412997
Locus: 4q12
PHF21A Gene Summary
The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
Gene Name: PHD Finger Protein 21A
Chromosome: CHR11: 45950869 -46142985
Locus: 11p11.2
Gene Diseases
The CLOCK PHF21A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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