CLK2-PPP1R12B Fusion FISH Probe
The CLK2-PPP1R12B Fusion FISH Probe is used to confirm a fusion of the CLK2 and PPP1R12B genes. The fusion of the CLK2 and PPP1R12B genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLK2-PPP1R12B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-RERE | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-REOR | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-REGO | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-REGR | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-REAQ | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-ORRE | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-OROR | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-ORGO | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-GORE | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-GOOR | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-GOGO | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-GOGR | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-GRRE | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-GROR | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-GRGO | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-GRGR | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-AQRE | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-AQOR | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-AQGO | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-AQGR | 20 (40 μL) | 200 μL |
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| CLK2-PPP1R12B-20-AQAQ | 20 (40 μL) | 200 μL |
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CLK2 Gene Summary
This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Name: CDC Like Kinase 2
Chromosome: CHR1: 155232658 -155243281
Locus: 1q22
PPP1R12B Gene Summary
Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]
Gene Name: Protein Phosphatase 1 Regulatory Subunit 12B
Chromosome: CHR1: 202317829 -202557697
Locus: 1q32.1
Gene Diseases
The CLK2 PPP1R12B Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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