CLIP1-ZCCHC8 Fusion FISH Probe
The CLIP1-ZCCHC8 Fusion FISH Probe is used to confirm a fusion of the CLIP1 and ZCCHC8 genes. The fusion of the CLIP1 and ZCCHC8 genes has been associated with Head And Neck Squamous Cell Carcinoma , Bladder Urothelial Carcinoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLIP1-ZCCHC8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-RERE | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-REOR | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-REGO | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-REGR | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-REAQ | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-ORRE | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-OROR | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-ORGO | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-GORE | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-GOOR | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-GOGO | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-GOGR | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-GRRE | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-GROR | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-GRGO | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-GRGR | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-AQRE | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-AQOR | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-AQGO | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-AQGR | 20 (40 μL) | 200 μL |
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| CLIP1-ZCCHC8-20-AQAQ | 20 (40 μL) | 200 μL |
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CLIP1 Gene Summary
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: CAP-Gly Domain Containing Linker Protein 1
Chromosome: CHR12: 122755980 -122907116
Locus: 12q24.31
ZCCHC8 Gene Summary
This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]
Gene Name: Zinc Finger CCHC-type Containing 8
Chromosome: CHR12: 122956145 -122985543
Locus: 12q24.31
Gene Diseases
The CLIP1 ZCCHC8 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
| Bladder Urothelial Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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