CLDN4-UTRN Fusion FISH Probe
The CLDN4-UTRN Fusion FISH Probe is used to confirm a fusion of the CLDN4 and UTRN genes. The fusion of the CLDN4 and UTRN genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLDN4-UTRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-RERE | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-REOR | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-REGO | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-REGR | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-REAQ | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-ORRE | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-OROR | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-ORGO | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-GORE | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-GOOR | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-GOGO | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-GOGR | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-GRRE | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-GROR | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-GRGO | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-GRGR | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-AQRE | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-AQOR | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-AQGO | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-AQGR | 20 (40 μL) | 200 μL |
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| CLDN4-UTRN-20-AQAQ | 20 (40 μL) | 200 μL |
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CLDN4 Gene Summary
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]
Gene Name: Claudin 4
Chromosome: CHR7: 73245192 -73247015
Locus: 7q11.23
UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
Gene Diseases
The CLDN4 UTRN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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