CLDN12-SPCS3 Fusion FISH Probe
The CLDN12-SPCS3 Fusion FISH Probe is used to confirm a fusion of the CLDN12 and SPCS3 genes. The fusion of the CLDN12 and SPCS3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLDN12-SPCS3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-RERE | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-REOR | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-REGO | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-REGR | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-REAQ | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-ORRE | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-OROR | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-ORGO | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-GORE | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-GOOR | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-GOGO | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-GOGR | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-GRRE | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-GROR | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-GRGO | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-GRGR | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-AQRE | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-AQOR | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-AQGO | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-AQGR | 20 (40 μL) | 200 μL |
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| CLDN12-SPCS3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLDN12 Gene Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, Sep 2011]
Gene Name: Claudin 12
Chromosome: CHR7: 90032647 -90045268
Locus: 7q21.13
SPCS3 Gene Summary
The Signal Peptidase Complex Subunit 3 (SPCS3) gene is located on chr4 :177241089-177253396 at 4q34.2.
Gene Name: Signal Peptidase Complex Subunit 3
Chromosome: CHR4: 177241089 -177253396
Locus: 4q34.2
Gene Diseases
The CLDN12 SPCS3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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