CLCN7-SEC63 Fusion FISH Probe
The CLCN7-SEC63 Fusion FISH Probe is used to confirm a fusion of the CLCN7 and SEC63 genes. The fusion of the CLCN7 and SEC63 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLCN7-SEC63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-RERE | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-REOR | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-REGO | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-REGR | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-REAQ | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-ORRE | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-OROR | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-ORGO | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-GORE | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-GOOR | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-GOGO | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-GOGR | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-GRRE | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-GROR | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-GRGO | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-GRGR | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-AQRE | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-AQOR | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-AQGO | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-AQGR | 20 (40 μL) | 200 μL |
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| CLCN7-SEC63-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN7 Gene Summary
The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq, Jul 2008]
Gene Name: Chloride Voltage-gated Channel 7
Chromosome: CHR16: 1494934 -1525085
Locus: 16p13.3
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The CLCN7 SEC63 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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