CLCN7-IFT140 Fusion FISH Probe
The CLCN7-IFT140 Fusion FISH Probe is used to confirm a fusion of the CLCN7 and IFT140 genes. The fusion of the CLCN7 and IFT140 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLCN7-IFT140-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-RERE | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-REOR | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-REGO | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-REGR | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-REAQ | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-ORRE | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-OROR | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-ORGO | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-GORE | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-GOOR | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-GOGO | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-GOGR | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-GRRE | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-GROR | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-GRGO | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-GRGR | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-AQRE | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-AQOR | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-AQGO | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-AQGR | 20 (40 μL) | 200 μL |
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| CLCN7-IFT140-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN7 Gene Summary
The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq, Jul 2008]
Gene Name: Chloride Voltage-gated Channel 7
Chromosome: CHR16: 1494934 -1525085
Locus: 16p13.3
IFT140 Gene Summary
This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. [provided by RefSeq, Jun 2012]
Gene Name: Intraflagellar Transport 140
Chromosome: CHR16: 1560427 -1662109
Locus: 16p13.3
Gene Diseases
The CLCN7 IFT140 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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