CLCN6-RAF1 Fusion FISH Probe
The CLCN6-RAF1 Fusion FISH Probe is used to confirm a fusion of the CLCN6 and RAF1 genes. The fusion of the CLCN6 and RAF1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLCN6-RAF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-RERE | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-REOR | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-REGO | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-REGR | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-REAQ | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-ORRE | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-OROR | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-ORGO | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-GORE | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-GOOR | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-GOGO | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-GOGR | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-GRRE | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-GROR | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-GRGO | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-GRGR | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-AQRE | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-AQOR | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-AQGO | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-AQGR | 20 (40 μL) | 200 μL |
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| CLCN6-RAF1-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN6 Gene Summary
This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]
Gene Name: Chloride Voltage-gated Channel 6
Chromosome: CHR1: 11866206 -11903201
Locus: 1p36.22
RAF1 Gene Summary
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
Gene Name: Raf-1 Proto-oncogene, Serine/threonine Kinase
Chromosome: CHR3: 12625099 -12705700
Locus: 3p25.2
Gene Diseases
The CLCN6 RAF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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