CLCN4-SHROOM2 Fusion FISH Probe
The CLCN4-SHROOM2 Fusion FISH Probe is used to confirm a fusion of the CLCN4 and SHROOM2 genes. The fusion of the CLCN4 and SHROOM2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLCN4-SHROOM2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-RERE | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-REOR | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-REGO | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-REGR | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-REAQ | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-ORRE | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-OROR | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-ORGO | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-GORE | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-GOOR | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-GOGO | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-GOGR | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-GRRE | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-GROR | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-GRGO | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-GRGR | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-AQRE | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-AQOR | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-AQGO | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-AQGR | 20 (40 μL) | 200 μL |
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| CLCN4-SHROOM2-20-AQAQ | 20 (40 μL) | 200 μL |
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SHROOM2 Gene Summary
This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Gene Name: Shroom Family Member 2
Chromosome: CHRX: 9754495 -9917481
Locus: Xp22.2
CLCN4 Gene Summary
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]
Gene Name: Chloride Voltage-gated Channel 4
Chromosome: CHRX: 10124984 -10205699
Locus: Xp22.2
Gene Diseases
The CLCN4 SHROOM2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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