CLCN3-TDO2 Fusion FISH Probe
The CLCN3-TDO2 Fusion FISH Probe is used to confirm a fusion of the CLCN3 and TDO2 genes. The fusion of the CLCN3 and TDO2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLCN3-TDO2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-RERE | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-REOR | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-REGO | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-REGR | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-REAQ | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-ORRE | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-OROR | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-ORGO | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-GORE | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-GOOR | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-GOGO | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-GOGR | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-GRRE | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-GROR | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-GRGO | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-GRGR | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-AQRE | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-AQOR | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-AQGO | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-AQGR | 20 (40 μL) | 200 μL |
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| CLCN3-TDO2-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
TDO2 Gene Summary
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
Gene Name: Tryptophan 2,3-dioxygenase
Chromosome: CHR4: 156824846 -156841550
Locus: 4q32.1
Gene Diseases
The CLCN3 TDO2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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