CLCN3-SMAD1 Fusion FISH Probe
The CLCN3-SMAD1 Fusion FISH Probe is used to confirm a fusion of the CLCN3 and SMAD1 genes. The fusion of the CLCN3 and SMAD1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLCN3-SMAD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-RERE | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-REOR | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-REGO | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-REGR | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-REAQ | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-ORRE | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-OROR | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-ORGO | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-GORE | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-GOOR | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-GOGO | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-GOGR | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-GRRE | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-GROR | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-GRGO | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-GRGR | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-AQRE | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-AQOR | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-AQGO | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-AQGR | 20 (40 μL) | 200 μL |
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| CLCN3-SMAD1-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
SMAD1 Gene Summary
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Gene Name: SMAD Family Member 1
Chromosome: CHR4: 146402950 -146480325
Locus: 4q31.21
Gene Diseases
The CLCN3 SMAD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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