CLCN3-PALLD Fusion FISH Probe
The CLCN3-PALLD Fusion FISH Probe is used to confirm a fusion of the CLCN3 and PALLD genes. The fusion of the CLCN3 and PALLD genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLCN3-PALLD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-RERE | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-REOR | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-REGO | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-REGR | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-REAQ | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-ORRE | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-OROR | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-ORGO | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-GORE | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-GOOR | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-GOGO | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-GOGR | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-GRRE | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-GROR | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-GRGO | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-GRGR | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-AQRE | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-AQOR | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-AQGO | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-AQGR | 20 (40 μL) | 200 μL |
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| CLCN3-PALLD-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
PALLD Gene Summary
This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Name: Palladin, Cytoskeletal Associated Protein
Chromosome: CHR4: 169418216 -169849608
Locus: 4q32.3
Gene Diseases
The CLCN3 PALLD Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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