CLCF1-PPP1CA Fusion FISH Probe
The CLCF1-PPP1CA Fusion FISH Probe is used to confirm a fusion of the CLCF1 and PPP1CA genes. The fusion of the CLCF1 and PPP1CA genes has been associated with Kidney Renal Papillary Cell Carcinoma, and Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLCF1-PPP1CA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-RERE | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-REOR | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-REGO | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-REGR | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-REAQ | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-ORRE | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-OROR | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-ORGO | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-GORE | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-GOOR | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-GOGO | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-GOGR | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-GRRE | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-GROR | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-GRGO | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-GRGR | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-AQRE | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-AQOR | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-AQGO | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-AQGR | 20 (40 μL) | 200 μL |
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| CLCF1-PPP1CA-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP1CA Gene Summary
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase 1 Catalytic Subunit Alpha
Chromosome: CHR11: 67165651 -67169376
Locus: 11q13.2
CLCF1 Gene Summary
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: Cardiotrophin Like Cytokine Factor 1
Chromosome: CHR11: 67131638 -67141648
Locus: 11q13.2
Gene Diseases
The CLCF1 PPP1CA Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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