CLASP1-FBXO11 Fusion FISH Probe
The CLASP1-FBXO11 Fusion FISH Probe is used to confirm a fusion of the CLASP1 and FBXO11 genes. The fusion of the CLASP1 and FBXO11 genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CLASP1-FBXO11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-RERE | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-REOR | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-REGO | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-REGR | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-REAQ | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-ORRE | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-OROR | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-ORGO | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-ORAQ | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-GORE | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-GOOR | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-GOGO | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-GOGR | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-GOAQ | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-GRRE | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-GROR | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-GRGO | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-GRGR | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-GRAQ | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-AQRE | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-AQOR | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-AQGO | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-AQGR | 20 (40 μL) | 200 μL |
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| CLASP1-FBXO11-20-AQAQ | 20 (40 μL) | 200 μL |
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CLASP1 Gene Summary
CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]
Gene Name: Cytoplasmic Linker Associated Protein 1
Chromosome: CHR2: 122095351 -122407052
Locus: 2q14.2-q14.3
FBXO11 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Gene Name: F-box Protein 11
Chromosome: CHR2: 48034058 -48132932
Locus: 2p16.3
Gene Diseases
The CLASP1 FBXO11 Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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