CKB-EIF2AK2 Fusion FISH Probe
The CKB-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the CKB and EIF2AK2 genes. The fusion of the CKB and EIF2AK2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CKB-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| CKB-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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CKB Gene Summary
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Creatine Kinase B
Chromosome: CHR14: 103985995 -103989170
Locus: 14q32.33
EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
Gene Diseases
The CKB EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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