CKAP5-DAAM1 Fusion FISH Probe
The CKAP5-DAAM1 Fusion FISH Probe is used to confirm a fusion of the CKAP5 and DAAM1 genes. The fusion of the CKAP5 and DAAM1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CKAP5-DAAM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-RERE | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-REOR | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-REGO | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-REGR | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-REAQ | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-ORRE | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-OROR | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-ORGO | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-GORE | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-GOOR | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-GOGO | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-GOGR | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-GRRE | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-GROR | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-GRGO | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-GRGR | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-AQRE | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-AQOR | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-AQGO | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-AQGR | 20 (40 μL) | 200 μL |
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| CKAP5-DAAM1-20-AQAQ | 20 (40 μL) | 200 μL |
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CKAP5 Gene Summary
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Cytoskeleton Associated Protein 5
Chromosome: CHR11: 46765083 -46867859
Locus: 11p11.2
DAAM1 Gene Summary
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
Gene Name: Dishevelled Associated Activator Of Morphogenesis 1
Chromosome: CHR14: 59655398 -59836471
Locus: 14q23.1
Gene Diseases
The CKAP5 DAAM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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