CIITA-PRDM16 Fusion FISH Probe
The CIITA-PRDM16 Fusion FISH Probe is used to confirm a fusion of the CIITA and PRDM16 genes. The fusion of the CIITA and PRDM16 genes has been associated with Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CIITA-PRDM16-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CIITA-PRDM16-20-AQAQ | 20 (40 μL) | 200 μL |
|
CIITA Gene Summary
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Name: Class II Major Histocompatibility Complex Transactivator
Chromosome: CHR16: 10971054 -11018840
Locus: 16p13.13
PRDM16 Gene Summary
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: PR/SET Domain 16
Chromosome: CHR1: 2985741 -3355185
Locus: 1p36.32
Gene Diseases
The CIITA PRDM16 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lymphoid Neoplasm Diffuse Large B-cell Lymphoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|